How do you grade evidence? |
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YOU NEED TO KNW THIS
Also see this link http://www.cebm.net/index.aspx?o=1047
Revised grading system for recommendations in evidence based guidelines
Levels of evidence
1++ High quality meta-analyses, systematic reviews of RCTs, or RCTs with a very low risk of bias
1+ Well conducted meta-analyses, systematic reviews of RCTs, or RCTs with a low risk of bias
1 Meta-analyses, systematic reviews or RCTs, or RCTs with a high risk of bias
2++ High quality systematic reviews of case-control or cohort studies or
High quality case-control or cohort studies with a very low risk of confounding, bias, or chance and a high probability that the relationship is causal
2+ Well conducted case-control or cohort studies with a low risk of confounding, bias, or chance and a moderate probability that the relationship is causal
2 Case-control or cohort studies with a high risk of confounding, bias, or chance and a significant risk that the relationship is not causal
3 Non-analytic studies, eg case reports, case series
4 Expert opinion
Grades of recommendations
A At least one meta-analysis, systematic review, or RCT rated as 1++ and directly applicable to the target population or
A systematic review of RCTs or a body of evidence consisting principally of studies rated as 1+ directly applicable to the target population and demonstrating overall consistency of results
B A body of evidence including studies rated as 2++ directly applicable to the target population and demonstrating overall consistency of results or
Extrapolated evidence from studies rated as 1++ or 1+
C A body of evidence including studies rated as 2+ directly applicable to the target population and demonstrating overall consistency of results or
Extrapolated evidence from studies rated as 2++
D Evidence level 3 or 4 or
Extrapolated evidence from studies rated as 2+
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