Guidelines for the critical appraisal of a paper
· Who wrote the paper?
· Do they or the institution have a proven academic record?
· Is the paper interesting and relevant?
Introduction
· Did the study introduction address the relevant points?
· Was the study original?
· Were the aims clearly stated?
Methods
· Was an appropriate group of subjects studies?
· How were subjects recruited?
· What were the inclusion criteria?
· What were the exclusion criteria?
· Was the sample size justified?
· Was a power calculation performed?
· Was the study design appropriate?
· Review - systematic or meta-analysis
· Drug treatment - randomised controlled trail
· Prognosis - cohort study
· Causation - case - control study
· Were the study groups comparable?
· Demographics, baseline criteria etc
· Was the assignment of patients to treatments randomised?
· How was the randomisation performed
· Were the groups treated equally other than for the experimental intervention?
· Were the outcome measures stated and relevant?
· Were measurements valid and reliable?
· Were patients and healthcare workers 'blinded' to the treatment given?
· Were all patients entered into the study properly accounted for?
· Is there any missing data?
· Were side effects and adverse outcome documented?
· Was the duration and completeness of follow up appropriate?
Statistics
· Were the statistical methods described?
· Does the tests chosen reflect the type of date
· Parametric versus parametric tests
· Were analyses performed on an intention to treat basis?
· Was systematic bias avoided or minimized?
Results
· How large was the treatment effect?
· How precise was the estimate of the treatment effect?
Discussion
· Were the aims of the study fulfilled?
· Were the sources of error discussed?
· Are the relevant findings justified?
· Are the conclusions of the paper justified?
· Are likely treatment benefits worth the potential harm or costs?
· What is the impact of the paper?
· Can the results be generalised to other populations?
· What do you think of the paper?
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